Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp179 | Cell biology: osteoblasts and bone formation | ECTS2013

Mineralizing properties of DMP1 studied in vitro with cellular and acellular 3D collagen model systems mimicking the bone tissue

Silvent Jeremie , Nassif Nadine , Azais Thierry , Helary Christophe , Delgado Sidney , Soncin Fabrice , Giraud-Guille Marie Madeleine , Sire Jean-Yves

Bone is a complex structure associating cells to an extracellular organic phase, including collagen and non collagenous proteins (NCPs), in close association with apatite mineral platelets. Although bone has given rise to extensive studies, the exact part played by NCPs in nucleating or inhibiting the mineral phase remains controversial. The present study aimed to better understand the functions of a major mineralizing protein, dentin matrix phosphoprotein 1 (DMP1), an acidic,...